Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Lysophospholipids are a class of bioactive lipid molecules that produce their effects through
various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is perhaps …

Abstract Sphingosine-1-phosphate receptor 1 (S1PR1) is a master regulator of lymphocyte
egress from the lymph node and an established drug target for multiple sclerosis (MS) …

Ischemic stroke, caused by a sudden disruption of blood flow to the brain, is a leading cause
of death and exerts a heavy burden on both patients and public health systems. Currently …

Rationale: Myocardial infarction (MI) is one of the most dangerous adverse cardiovascular
events. Our previous study found that lysophosphatidic acid (LPA) is increased in human …

The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …

Siponimod is a selective sphingosine 1-phosphate receptor subtype 1 (S1P1) and 5 (S1P5)
modulator approved in the United States and the European Union as an oral treatment for …

Sphingolipids are crucial molecules of the mammalian epidermis. The formation of skin-
specific ceramides contributes to the formation of lipid lamellae, which are important for the …

Lipids play an important role in neurodegeneration, neuroinflammation, and psychiatric
disorders and an imbalance in sphingolipid levels is associated with disease. Although early …

Seizures are a common presenting symptom during viral infections of the central nervous
system (CNS) and can occur during the initial phase of infection (“early” or acute …