Loss of tumor suppressor gene function in human cancer: an overview
LH Wang, CF Wu, N Rajasekaran… - Cellular Physiology and …, 2019 - karger.com
Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …
[HTML][HTML] Smad4-mediated TGF-β signaling in tumorigenesis
G Yang, X Yang - International journal of biological sciences, 2010 - ncbi.nlm.nih.gov
Transforming growth factor-β (TGF-β) family members exert their function via specific type I
and type II serine/threonine kinase receptors and intracellular Smad transcription factors …
and type II serine/threonine kinase receptors and intracellular Smad transcription factors …
SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy
F Wang, X Xia, C Yang, J Shen, J Mai, HC Kim… - Clinical Cancer …, 2018 - AACR
Purpose: Understanding the mechanism of radioresistance could help develop strategies to
improve therapeutic response of patients with PDAC. The SMAD4 gene is frequently …
improve therapeutic response of patients with PDAC. The SMAD4 gene is frequently …
Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm
AJ Doyle, JJ Doyle, SL Bessling, S Maragh… - Nature …, 2012 - nature.com
Elevated transforming growth factor (TGF)-β signaling has been implicated in the
pathogenesis of syndromic presentations of aortic aneurysm, including Marfan syndrome …
pathogenesis of syndromic presentations of aortic aneurysm, including Marfan syndrome …
The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma
J Liu, G Ren, K Li, Z Liu, Y Wang, T Chen… - Cell Death & …, 2022 - nature.com
Cholangiocarcinoma (CCA), consisting of three subtypes-intrahepatic (iCCA), perihilar
(pCCA), and distal (dCCA), is a highly aggressive cancer arising from the bile duct and has …
(pCCA), and distal (dCCA), is a highly aggressive cancer arising from the bile duct and has …
Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer
R Shen, S Pan, S Qi, X Lin, S Cheng - Biochemical and biophysical …, 2010 - Elsevier
High levels of SOX4 expression have been found in a variety of human cancers, such as
lung, brain and breast cancers. However, the expression of SOX4 in gastric tissues remains …
lung, brain and breast cancers. However, the expression of SOX4 in gastric tissues remains …
S100A2 induces epithelial–mesenchymal transition and metastasis in pancreatic cancer by coordinating transforming growth factor β signaling in SMAD4-dependent …
Q Chen, H Guo, H Jiang, Z Hu, X Yang, Z Yuan… - Cell Death …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor and is associated
with a poor prognosis. Treatment strategies for PDAC are largely ineffective primarily …
with a poor prognosis. Treatment strategies for PDAC are largely ineffective primarily …
Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells
Expression level of metastasis-associated protein 1 (MTA1) is closely related to tumor
growth and metastasis in various cancers. Although increased expression level of MTA1 …
growth and metastasis in various cancers. Although increased expression level of MTA1 …
miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway
GL Sun, Z Li, WZ Wang, Z Chen, L Zhang, Q Li… - Journal of …, 2018 - Springer
Background Emerging evidence suggested that miRNAs can function as oncogenes or
tumor suppressors by regulating downstream target genes. miR-324-3p has been reported …
tumor suppressors by regulating downstream target genes. miR-324-3p has been reported …
Whole-genome reconstruction and mutational signatures in gastric cancer
Background Gastric cancer is the second highest cause of global cancer mortality. To
explore the complete repertoire of somatic alterations in gastric cancer, we combined …
explore the complete repertoire of somatic alterations in gastric cancer, we combined …