Loss of tumor suppressor gene function in human cancer: an overview

LH Wang, CF Wu, N Rajasekaran… - Cellular Physiology and …, 2019 - karger.com
Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

[HTML][HTML] Smad4-mediated TGF-β signaling in tumorigenesis

G Yang, X Yang - International journal of biological sciences, 2010 - ncbi.nlm.nih.gov
Transforming growth factor-β (TGF-β) family members exert their function via specific type I
and type II serine/threonine kinase receptors and intracellular Smad transcription factors …

SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy

F Wang, X Xia, C Yang, J Shen, J Mai, HC Kim… - Clinical Cancer …, 2018 - AACR
Purpose: Understanding the mechanism of radioresistance could help develop strategies to
improve therapeutic response of patients with PDAC. The SMAD4 gene is frequently …

Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm

AJ Doyle, JJ Doyle, SL Bessling, S Maragh… - Nature …, 2012 - nature.com
Elevated transforming growth factor (TGF)-β signaling has been implicated in the
pathogenesis of syndromic presentations of aortic aneurysm, including Marfan syndrome …

The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma

J Liu, G Ren, K Li, Z Liu, Y Wang, T Chen… - Cell Death & …, 2022 - nature.com
Cholangiocarcinoma (CCA), consisting of three subtypes-intrahepatic (iCCA), perihilar
(pCCA), and distal (dCCA), is a highly aggressive cancer arising from the bile duct and has …

Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer

R Shen, S Pan, S Qi, X Lin, S Cheng - Biochemical and biophysical …, 2010 - Elsevier
High levels of SOX4 expression have been found in a variety of human cancers, such as
lung, brain and breast cancers. However, the expression of SOX4 in gastric tissues remains …

S100A2 induces epithelial–mesenchymal transition and metastasis in pancreatic cancer by coordinating transforming growth factor β signaling in SMAD4-dependent …

Q Chen, H Guo, H Jiang, Z Hu, X Yang, Z Yuan… - Cell Death …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor and is associated
with a poor prognosis. Treatment strategies for PDAC are largely ineffective primarily …

Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells

YG Yoo, TY Na, HW Seo, JK Seong, CK Park, YK Shin… - Oncogene, 2008 - nature.com
Expression level of metastasis-associated protein 1 (MTA1) is closely related to tumor
growth and metastasis in various cancers. Although increased expression level of MTA1 …

miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway

GL Sun, Z Li, WZ Wang, Z Chen, L Zhang, Q Li… - Journal of …, 2018 - Springer
Background Emerging evidence suggested that miRNAs can function as oncogenes or
tumor suppressors by regulating downstream target genes. miR-324-3p has been reported …

Whole-genome reconstruction and mutational signatures in gastric cancer

N Nagarajan, D Bertrand, AM Hillmer, ZJ Zang, F Yao… - Genome biology, 2012 - Springer
Background Gastric cancer is the second highest cause of global cancer mortality. To
explore the complete repertoire of somatic alterations in gastric cancer, we combined …