Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Cellular senescence is now considered an important driving mechanism for chronic lung
diseases, particularly chronic obstructive pulmonary disease (COPD) and idiopathic …

The differentiation of T helper cell subsets and their acquisition of effector functions are
accompanied by changes in gene expression programmes, which in part are regulated and …

Fibrosis, which is characterized by excessive extracellular matrix (ECM) deposition, is a
wound-healing response to organ injury and may promote cancer and failure in various …

Fibrotic lung diseases qualify among the most dreaded irreversible interstitial pulmonary
complications with progressive yet largely unpredictable clinical course. Idiopathic …

Allergic inflammation is a T helper 2 (Th2) cell-driven pathophysiological phenomenon, but
the mechanism by which the metabolic cascade affects Th2 cell differentiation remains …

Cigarette smoke impairs autophagy, an intracellular protein degradation system, but the
consequences of this defect have not been fully elucidated, especially in macrophages …

Information for Category 1 CME Credit Credit can now be obtained, free for a limited time, by
reading the review articles in this issue. Please note the following instructions. Method of …

Sirtuins are NAD-dependent class III histone deacetylase, which modulate the epigenetic
changes to influence the functions in normal and diseased conditions. Preclinical studies …

Background/Aims: A growing number of studies have demonstrated that the activity and
expression level of sirtuin-1 (SIRT1) are decreased in asthma patients; however, the …