Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Traumatic brain injury leads to cellular damage which in turn results in the rapid release of
damage-associated molecular patterns (DAMPs) that prompt resident cells to release …

Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …

Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

Nerve injury triggers the conversion of myelin and non‐myelin (Remak) Schwann cells to a
cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells …

The injured spinal cord does not heal properly. In contrast, tissue repair and functional
recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is …

Once their safety is confirmed, human-induced pluripotent stem cells (hiPSCs), which do not
entail ethical concerns, may become a preferred cell source for regenerative medicine …

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …