The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

Ageing is a multi-factorial phenomenon which is considered as a major risk factor for the
development of neurodegeneration, osteoporosis, cardiovascular disease, dementia …

Cellular senescence is caused by a wide range of intracellular and extracellular stimuli and
influences physiological functions, leading to the progression of age-related diseases. Many …

Reactive oxygen species (ROS) are a key risk factor of cellular senescence and age-related
diseases, and protein kinase C (PKC) has been shown to activate NADPH oxidases (NOXs) …

Purpose: The PI3K/Akt signaling pathway regulates cell growth, proliferation and viability in
hematopoietic cells. This pathway always dysregulates in acute lymphoblastic leukemia …

People are living longer than ever. Consequently, they have a greater chance for
developing a functional impairment or aging-related disease, such as a neurodegenerative …

Mutations in the well-known tumor suppressor PTEN are observed in many cancers. PTEN
is a dual-specificity phosphatase that harbors lipid and protein-phosphatase activities. The …

The incidence and mortality rate of atherosclerotic cardiovascular disease (ASCVD) is
increasing yearly worldwide. Recently, a growing body of evidence has unveiled the anti …

Background Early onset gastric cancer (EOGC) has been on the rise in recent years and
differs slightly in pathology from traditional gastric cancer (TGC). Somatic mutations have an …

Motivation Epigenetic ageing clocks based on age-associated changes in DNA-methylation
(DNAm) profiles have shown great potential as predictors to quantify age-related health and …