Pathogenesis by mycobacteria requires the exploitation of host-cell signalling pathways to
enhance the intracellular survival and persistence of the pathogen. The disruption of these …

The ability of a host to sense invasion by pathogenic organisms and to respond
appropriately to control infection is paramount to survival. In the case of sepsis and septic …

Successful phagolysosomal maturation is an important innate immune response to
intracellular infection. However, Mycobacterium tuberculosis (Mtb) can manipulate and …

Sarcoidosis is a polygenic immune disorder with predominant manifestation in the lung.
Genome-wide linkage analysis previously indicated that the extended major …

Microarray-assisted gene-expression screens of human macrophages revealed WNT5A, a
homolog of Wingless, a key regulator of Drosophila melanogaster embryonic segmentation …

The pathophysiological functions of proline-glutamic acid (PE)/proline-proline-glutamic acid
(PPE) family of proteins of Mycobacterium tuberculosis are not well understood. In this study …

Tumor necrosis factor alpha (TNF-α) is a potent cytokine which regulates inflammation via
the induction of adhesion molecules and chemokine expression. Its expression is known to …

Wnt proteins are secreted, palmitoylated glycoproteins with multiple functions in cell
proliferation and migration as well as tissue organization. They are best known for their role …

In infection experiments with genetically distinct Mycobacterium tuberculosis complex
(MTBC) strains, we identified clade-specific virulence patterns in human primary …

Mycobacteria activate a series of macrophage signalling pathways upon engaging host cell
receptors and during the invasion process. These signals initiate a cascade of events …