Polyomavirus infection is widespread in the human population. This family of viruses
normally maintains latent infection within the host cell but can cause a range of human …

Bidirectional interactions between astrocytes and neurons have physiological roles in the
central nervous system and an altered state or dysfunction of such interactions may be …

The human fetal glial cell line SVG was generated in 1985 by transfecting primary fetal brain
cells with a plasmid containing an origin-defective mutant of simian virus 40 (SV40). The …

Mutations in the isocitrate dehydrogenase 1 (IDH1) gene have been identified in a number
of cancer types, including brain cancer. The Cancer Genome Atlas project has revealed that …

Progressive multifocal leukoencephalopathy (PML) is a frequent neurological complication
in immunosuppressed patients. PML is caused by the JC virus (JCV), a neurotropic DNA …

A novel polysaccharide EtGIPL1a was purified from fruiting bodies of Echinodontium
tinctorium, a fungus unique to western North America. EtGIPL1a has an estimated weight …

Merkel cell polyomavirus (MCPyV) is the first human polyomavirus etiologically associated
with Merkel cell carcinoma (MCC), a rare and aggressive form of skin cancer. Similar to …

ABSTRACT JC polyomavirus (JCPyV) infects 50 to 80% of the population and is the
causative agent of a fatal demyelinating disease of the central nervous system (CNS) …

Glioblastomas are the most aggressive of malignant brain cancers with a median patient
survival of approximately 18 months. We recently demonstrated that Tet methylcytosine …

Merkel cell carcinoma (MCC) is a rare and aggressive form of skin cancer that metastasizes
rapidly and resists most current therapies. Approximately 80% of MCC tumors are …