Cancer is one of the most common causes of death; in parallel, the incidence and
prevalence of central nervous system diseases are equally high. Among neurodegenerative …

Covering: 2011 to 2021 The structural division of ansamycins, including those of atypical
cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid …

The 90 kDa heat shock proteins (Hsp90) are responsible for the conformational maturation
of nascent polypeptides and the rematuration of denatured proteins. Proteins dependent …

Latency allows HIV-1 to persist in long-lived cellular reservoirs, preventing virus eradication.
We have previously shown that the heat shock protein 90 (Hsp90) is required for HIV-1 gene …

Background: A growing body of epidemiologic evidence suggests that neurodegenerative
diseases occur less frequently in cancer survivors, and vice versa. While unusual, this …

Neurodegenerative disease is one of the greatest health concerns today and with no
effective treatment in sight, it is crucial that researchers find a safe and successful …

The metal-free cascade transformation of geldanamycin benzoquinone core is proposed at
relatively mild conditions. This approach yields new benzoxazole ansamycin antibiotics and …

Geldanamycin (GDM) has been modified by different type neutral/acidic/basic substituents
(1–7) and by quinuclidine motif (8), transformed into ammonium salts (9–13) at C (17) …

Geldanamycin remains a driver in the medicinal chemistry of heat shock protein 90 (Hsp90)
inhibition, even half a century after its original isolation from nature. This Perspective focuses …

Autophagy functions as the primary cellular mechanism for clearing unwanted intracellular
contents. Emerging evidence suggests that the selective elimination of intracellular …