Interest in nitroheterocyclic drugs for the treatment of infectious diseases has undergone a
resurgence in recent years. Here we review the current status of monocyclic and bicyclic …

Introduction Carbonic anhydrase (CA) arose significant interest as a potential new target for
Chagas disease since its discovery in Trypanosoma cruzi in 2013. Benznidazole and …

Abstract In 2019, tuberculosis (TB) caused approximately 1.4 million deaths around the
world. TB is an infectious respiratory disease mainly caused by Mycobacterium tuberculosis …

More than 10 million people around the world are afflicted by Neglected Tropical Diseases,
such as Chagas Disease, Human African Trypanosomiasis, and Leishmania. These …

The concept of rational treatment, target to therapy, is an old and interesting process in drug
discovery that includes the entire step from target identification to successful treatments of …

Although the precise host‐defence mechanisms are not completely understood, T‐cell‐
mediated immune responses are believed to play a pivotal role in controlling parasite …

We report here a Leishmania donovani ornithine decarboxylase (Ld-ODC) gene used as a
DNA vaccine against visceral leishmaniasis in a murine Balb/c mouse model. This study …

The diagnosis of visceral leishmaniasis (VL) is one of the foremost barriers in the control of
this disease, as demonstration of the parasite by splenic/bone marrow aspiration is relatively …

Leishmaniasis, a parasitic infectious disease transmitted by sandfly bites, is an extremely
complex human and veterinary disease. In humans, it takes different forms ranging from self …

The crystallographic structure of the Leishmania donovani serine hydroxymethyltransferase
(Ld SHMT), an attractive target for the design of leishmanicidal agents, is still unknown …