The CLU-files: disentanglement of a mystery

P Rohne, H Prochnow, C Koch-Brandt - Biomolecular concepts, 2016 - degruyter.com
The multifaceted protein clusterin (CLU) has been challenging researchers for more than 35
years. The characterization of CLU as a molecular chaperone was one of the major …

A single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization

R Zhang, Q Liu, S Pan, Y Zhang, Y Qin, X Du… - Nature …, 2023 - nature.com
The six species of lungfish possess both lungs and gills and are the closest extant relatives
of tetrapods. Here, we report a single-cell transcriptome atlas of the West African lungfish …

Investigation of the Molecular Mechanisms of Antioxidant Damage and Immune Response Downregulation in Liver of Coilia nasus Under Starvation Stress

M Wang, G Xu, Y Tang, S Su, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Commercial fishing of estuarine tapertail anchovy (Coilia nasus), an important anadromous
fish species in the Yangtze River of China, has been prohibited due to the serious damage …

Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking …

MA Abdullah, YR Lee, SN Mastuki, SW Leong… - Bioorganic …, 2020 - Elsevier
Abstract A series of aminated-(1–9) and sulfonamide-containing diarylpentadienones (10–
18) were synthesized, structurally characterized, and evaluated for their in vitro anti-diabetic …

PoClu, a teleost Clusterin, acts as a negative regulator in complement activation and antibacterial immunity

G Chen, J Feng, W Shi, H Wang, J Zhang, X Li - Aquaculture, 2023 - Elsevier
Abstract In mammals, Clusterin (Clu) is a pleiotropic glycoprotein associated with various
physiological and pathological functions, and plays significant roles in innate immunity …

Preliminary Insight of Pyrrolylated-Chalcones as New Anti-Methicillin-Resistant Staphylococcus aureus (Anti-MRSA) Agents

M Gunasekharan, TI Choi, Y Rukayadi… - Molecules, 2021 - mdpi.com
Bacterial infections are regarded as one of the leading causes of fatal morbidity and death in
patients infected with diseases. The ability of microorganisms, particularly methicillin …

Deletion of clusterin protects cochlear hair cells against hair cell aging and ototoxicity

X Zhao, HJ Henderson, T Wang, B Liu, Y Li - Neural Plasticity, 2021 - Wiley Online Library
Hearing loss is a debilitating disease that affects 10% of adults worldwide. Most
sensorineural hearing loss is caused by the loss of mechanosensitive hair cells in the …

Expression of miRNA‐122 Induced by Liver Toxicants in Zebrafish

HS Nam, KS Hwang, YM Jeong, JI Ryu… - BioMed Research …, 2016 - Wiley Online Library
MicroRNA‐122 (miRNA‐122), also known as liver‐specific miRNA, has recently been
shown to be a potent biomarker in response to liver injury in mammals. The objective of this …

Molecular delineation, expression profiling, immune response, and anti-apoptotic function of a novel clusterin homolog from big-belly seahorse (Hippocampus …

H Wijerathna, K Nadarajapillai, HMV Udayantha… - Fish & Shellfish …, 2022 - Elsevier
Clusterin (CLU) is a glycoprotein that contains α-and β-chains. CLU exerts multifunctional
activities and plays a role in different cell signaling pathways that are associated with …

Camel regulates development of the brain ventricular system

S Yang, A Emelyanov, MS You, M Sin… - Cell and Tissue Research, 2021 - Springer
Abstract Development of the brain ventricular system of vertebrates and the molecular
mechanisms involved are not fully understood. The developmental genes expressed in the …