Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

The mechanisms that link visceral mechanosensation to the perception of internal organ
status (ie, interoception) remain elusive. In response to bladder filling, the urothelium …

Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and
pathophysiological processes via its ability to support release of ATP and other cellular …

Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed
throughout the body. Panx1 activation results in the release of nucleotides such as …

The internal face of the detrusor smooth muscle wall of the urinary bladder is covered by a
mucosa, separating muscle from the hostile environment of urine. However, the mucosa is …

Opiates are essential for treating pain, but termination of opiate therapy can cause a
debilitating withdrawal syndrome in chronic users. To alleviate or avoid the aversive …

Background Lower urinary tract syndrome (LUTS) is a group of urinary tract symptoms and
signs that can include urinary incontinence. Advancing age is a major risk factor for LUTS; …

Organs and tissues and their constituent cells are physiologically submitted to diverse types
of mechanical forces or stress, one common sequence of which is release of intracellular …