Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …

Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …

Multidomain proteins with flexible linkers and disordered regions play important roles in
many cellular processes, but characterizing their conformational ensembles is difficult. We …

The formation and viscoelastic properties of condensates of intrinsically disordered proteins
(IDPs) is dictated by amino acid sequence and solution conditions. Because of the …

Disordered proteins and nucleic acids can condense into droplets that resemble the
membraneless organelles observed in living cells. MD simulations offer a unique tool to …

Compartmentalization by liquid-liquid phase separation (LLPS) has emerged as a
ubiquitous mechanism underlying the organization of biomolecules in space and time. Here …

Growing evidence suggests prevalence of transcriptional condensates on chromatin, yet
their mechanisms of formation and functional significance remain largely unclear. In human …

Pathological tau aggregation is a primary neuropathological feature of many
neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates …

Post‐translational modifications (PTMs) have emerged as key modulators of protein phase
separation and have been linked to protein aggregation in neurodegenerative disorders …