Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Atherosclerosis is an inflammatory disease resulting in the hardening and thickening of the
wall of arteries and the formation of plaques, which comprise immune cells, mesenchymal …

Abstract Background The cJun-N-terminal-kinase (JNK) plays a central role in the cell stress
response, with outcomes ranging from cell death to cell proliferation and survival, depending …

Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall
(radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress) …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …

Located in the innermost layer of the vasculature and directly interacting with blood flow,
endothelium integrates various biochemical and biomechanical signals to maintain barrier …

Objective—Atherosclerosis develops near branches and bends of arteries that are exposed
to low shear stress (mechanical drag). These sites are characterized by excessive …

Rationale: Superficial erosion currently causes up to a third of acute coronary syndromes;
yet, we lack understanding of its mechanisms. Thrombi because of superficial intimal …