The roles of extracellular vesicles in the immune system

EI Buzas - Nature Reviews Immunology, 2023 - nature.com
The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

Extracellular vesicles arising from apoptosis: Forms, functions, and applications

CD Gregory, MP Rimmer - The Journal of Pathology, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayer‐enclosed subcellular bodies produced by most,
if not all cells. Research over the last two decades has recognised the importance of EVs in …

Apoptotic bodies: mechanism of formation, isolation and functional relevance

JP Santavanond, SF Rutter, GK Atkin-Smith… - New Frontiers …, 2021 - Springer
In the final stages of apoptosis, apoptotic cells can generate a variety of membrane-bound
vesicles known as apoptotic extracellular vesicles (ApoEVs). Apoptotic bodies (ApoBDs), a …

Translating extracellular vesicle packaging into therapeutic applications

DC Ozkocak, TK Phan, IKH Poon - Frontiers in immunology, 2022 - frontiersin.org
Extracellular vesicles (EVs) are membrane-bound particles released by cells in various
(patho) physiological conditions. EVs can transfer effector molecules and elicit potent …

Unleashing the therapeutic potential of apoptotic bodies

TK Phan, DC Ozkocak, IKH Poon - Biochemical society …, 2020 - portlandpress.com
Extracellular vesicles (EVs), membrane-bound vesicles that are naturally released by cells,
have emerged as new therapeutic opportunities. EVs, particularly exosomes and …

Hijacking homeostasis: Regulation of the tumor microenvironment by apoptosis

CD Gregory - Immunological reviews, 2023 - Wiley Online Library
Cancers are genetically driven, rogue tissues which generate dysfunctional, obdurate
organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved …

Microglial extracellular vesicles as vehicles for neurodegeneration spreading

ID Aires, T Ribeiro-Rodrigues, R Boia… - Biomolecules, 2021 - mdpi.com
Microglial cells are the neuroimmune competent cells of the central nervous system. In the
adult, microglia are responsible for screening the neuronal parenchyma searching for …

Characteristics of culture-condition stimulated exosomes or their loaded hydrogels in comparison with other extracellular vesicles or MSC lysates

Y Luo, Z Li, X Wang, J Wang, X Duan, R Li… - … in Bioengineering and …, 2022 - frontiersin.org
Recently, it has become popular to study the use of extracellular vesicles (EVs) secreted by
stem cells to repair damaged tissues or lost cells. Various cell types and physiological fluids …

Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells

GK Atkin-Smith - Biochemical Society Transactions, 2021 - portlandpress.com
Although millions of cells in the human body will undergo programmed cell death each day,
dying cells are rarely detected under homeostatic settings in vivo. The swift removal of dying …

Apoptotic Vesicles of MSCs: The Natural Therapeutic Agents and Bio‐Vehicles for Targeting Drug Delivery

R Lin, T Zhang, J Gao - Small, 2023 - Wiley Online Library
Mesenchymal stem cell (MSC)‐based therapies are increasingly recognized as promising
cellular therapeutics and show the ability to treat various diseases. However, the underlying …