Abstract Background Hepatitis C virus (HCV) is a leading cause of chronic liver disease, end-
stage cirrhosis, and liver cancer, but little is known about the burden of disease caused by …

Background: Patients with end-stage liver disease (ESLD) have a life-limiting illness that
causes multiple distressing symptoms and negatively affects quality of life (QOL). This …

Clinical experience suggests that many symptoms occur together. In this paper, we examine
the rationale and evidence base for symptom clusters in different medical fields, particularly …

Background Chronic hepatitis C (CHC) is the most common blood-borne infection in the
United States, but little is known about illness uncertainty in these patients. Objective The …

Objective: To explore psychosocial factors that impact on quality of life for people living with
self-reported chronic hepatitis C. Methods: A purposeful sample of 70 people who were self …

Background & Aims A comprehensive analysis of changes in symptoms and functioning
during and after direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) …

BACKGROUND & AIMS: Fatigue is the most frequent and often debilitating symptom of
chronic hepatitis C. It is unclear whether successful therapy of hepatitis C leads to its clinical …

Sleep disturbance is a common feature of chronic liver disease (CLD) with impact on health-
related quality of life; 60–80% of patients with CLD report subjective poor sleep; frequent …

Background Symptom burden, medical comorbidities, and functional well-being of patients
with chronic hepatitis C virus (HCV) initiating direct acting antiviral (DAA) therapy in real …

Feeling irritable is a common experience, both in health and disease. In the context of
psychiatric illnesses, it is a transdiagnostic phenomenon that features across all ages, and …