High-density diffuse optical tomography for imaging human brain function

MD Wheelock, JP Culver, AT Eggebrecht - Review of Scientific …, 2019 - pubs.aip.org
This review describes the unique opportunities and challenges for noninvasive optical
mapping of human brain function. Diffuse optical methods offer safe, portable, and radiation …

Clinical brain monitoring with time domain NIRS: a review and future perspectives

F Lange, I Tachtsidis - Applied Sciences, 2019 - mdpi.com
Near-infrared spectroscopy (NIRS) is an optical technique that can measure brain tissue
oxygenation and haemodynamics in real-time and at the patient bedside allowing medical …

Large-area, fast-gated digital SiPM with integrated TDC for portable and wearable time-domain NIRS

E Conca, V Sesta, M Buttafava, F Villa… - IEEE Journal of Solid …, 2020 - ieeexplore.ieee.org
We present the design and characterization of a large-area, fast-gated, all-digital single-
photon detector with programmable active area, internal gate generator, and time-todigital …

Optical characterization of porcine tissues from various organs in the 650–1100 nm range using time-domain diffuse spectroscopy

S Mosca, P Lanka, N Stone, SKV Sekar… - Biomedical optics …, 2020 - opg.optica.org
We present a systematic characterization of the optical properties (µ_a and µ_s') of nine
representative ex vivo porcine tissues over a broadband spectrum (650-1100 nm). We …

High resolution, deep imaging using confocal time-of-flight diffuse optical tomography

Y Zhao, A Raghuram, HK Kim… - … on Pattern Analysis …, 2021 - ieeexplore.ieee.org
Light scattering by tissue severely limits how deep beneath the surface one can image, and
the spatial resolution one can obtain from these images. Diffuse optical tomography (DOT) is …

The SiPM revolution in time-domain diffuse optics

A Dalla Mora, L Di Sieno, A Behera, P Taroni… - Nuclear Instruments and …, 2020 - Elsevier
Time-domain diffuse optics is a powerful non-invasive, non-ionizing and label-free
technique based on the use of picosecond pulsed laser light to probe highly scattering …

Broadband time domain diffuse optical reflectance spectroscopy: a review of systems, methods, and applications

S Konugolu Venkata Sekar, P Lanka, A Farina… - Applied Sciences, 2019 - mdpi.com
This review presents recent developments and a wide overview of broadband time domain
diffuse optical spectroscopy (TD-DOS). Various topics including physics of photon migration …

Time-gated single-photon detection in time-domain diffuse optics: a review

A Dalla Mora, L Di Sieno, R Re, A Pifferi, D Contini - Applied Sciences, 2020 - mdpi.com
This work reviews physical concepts, technologies and applications of time-domain diffuse
optics based on time-gated single-photon detection. This particular photon detection …

Incorporating early and late-arriving photons to improve the reconstruction of cerebral hemodynamic responses acquired by time-resolved near-infrared spectroscopy

D Milej, A Abdalmalak, A Rajaram… - Journal of …, 2021 - spiedigitallibrary.org
Significance: Despite its advantages in terms of safety, low cost, and portability, functional
near-infrared spectroscopy applications can be challenging due to substantial signal …

Optics based label-free techniques and applications in brain monitoring

P Karthikeyan, S Moradi, H Ferdinando, Z Zhao… - Applied Sciences, 2020 - mdpi.com
Functional near-infrared spectroscopy (fNIRS) has been utilized already around three
decades for monitoring the brain, in particular, oxygenation changes in the cerebral cortex …