Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of
which have been extensively studied. Although initially thought to constitute mutually …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Oxidative stress-induced granulosa cell (GCs) death represents a common reason for
follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from …

Sirtuin genes have been associated with aging and are known to affect multiple cellular
pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age …

Oxidative stress has been described as a prime driver of granulosa cell (GCs) death during
follicular atresia. Increasing evidence suggests potential roles of melatonin in protecting …

Autophagy is a highly regulated catabolic process that involves lysosomal degradation of
proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis …

Genetic abnormalities have been conventionally considered as hallmarks of cancer.
However, studies over the past decades have demonstrated that epigenetic regulation also …