From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan
(GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and …

Background: The recent availability of genetic analyses has demonstrated the shortcomings
of the current phenotypic method of corneal dystrophy classification. Abnormalities in …

Keratan sulfate was originally identified as the major glycosaminoglycan of cornea but is
now known to modify at least a dozen different proteins in a wide variety of tissues. Despite a …

The ocular surface, which forms the interface between the eye and the external environment,
includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that …

[Frontiers in Bioscience 8, d687-713, May 1, 2003] 687 THE MOLECULAR GENETICS OF THE
CORNEAL DYSTROPHIES – CURRENT STATUS Gord Page 1 [Frontiers in Bioscience 8 …

About 250 to 500 glycogenes (genes that are directly involved in glycan metabolism) are in
the human genome representing about 1–2% of the total genome. Over 40 human …

Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan
sulfate are covalently attached to specific core proteins to form proteoglycans, which are …

Nutrient sulfate is essential for numerous physiological functions in mammalian growth and
development. Accordingly, disruptions to any of the molecular processes that maintain the …

Matrix assembly and homeostasis in collagen-rich tissues are mediated by interactions with
proteoglycans (PGs) substituted with sulfated glycosaminoglycans (GAGs). The major GAG …

Purpose.: Recently, a novel gene was cloned for autosomal recessive retinitis pigmentosa
(arRP), EYS, on 6q12. This study was conducted to determine the spectrum and frequency …