Glaucoma: the retina and beyond

BM Davis, L Crawley, M Pahlitzsch, F Javaid… - Acta …, 2016 - Springer
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …

The role of lamina cribrosa tissue stiffness and fibrosis as fundamental biomechanical drivers of pathological glaucoma cupping

AA Hopkins, R Murphy, M Irnaten… - … of Physiology-Cell …, 2020 - journals.physiology.org
The primary biomechanical driver of pathological glaucomatous cupping remains unknown.
Finite element modeling indicates that stress and strain play key roles. In this article …

[HTML][HTML] Cerebrospinal fluid pressure: revisiting factors influencing optic nerve head biomechanics

Y Hua, AP Voorhees, IA Sigal - Investigative ophthalmology & …, 2018 - jov.arvojournals.org
Purpose: To model the sensitivity of the optic nerve head (ONH) biomechanical environment
to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery …

Lamina cribrosa pore shape and size as predictors of neural tissue mechanical insult

AP Voorhees, NJ Jan, ME Austin… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: The purpose of this study was to determine how the architecture of the lamina
cribrosa (LC) microstructure, including the shape and size of the lamina pores, influences …

So-called lamina cribrosa defects may mitigate IOP-induced neural tissue insult

AP Voorhees, Y Hua, BL Brazile… - … & Visual Science, 2020 - iovs.arvojournals.org
Purpose: The prevailing theory about the function of lamina cribrosa (LC) connective tissues
is that they provide structural support to adjacent neural tissues. Missing connective tissues …

Role of radially aligned scleral collagen fibers in optic nerve head biomechanics

Y Hua, AP Voorhees, NJ Jan, B Wang… - Experimental eye …, 2020 - Elsevier
Collagen fibers organized circumferentially around the canal in the peripapillary sclera are
thought to provide biomechanical support to the sensitive tissues within the optic nerve head …

Quantification of material constants for a phenomenological constitutive model of porcine tricuspid valve leaflets for simulation applications

KA Khoiy, AD Pant, R Amini - Journal of …, 2018 - asmedigitalcollection.asme.org
The tricuspid valve is a one-way valve on the pulmonary side of the heart, which prevents
backflow of blood during ventricular contractions. Development of computational models of …

Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell

TY Foong, Y Hua, R Amini, IA Sigal - Experimental eye research, 2023 - Elsevier
Collagen is the main load-bearing component of cornea and sclera. When stretched, both of
these tissues exhibit a behavior known as collagen fiber recruitment. In recruitment, as the …

Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa

Y Hua, Y Lu, J Walker, PY Lee, Q Tian… - Experimental eye …, 2022 - Elsevier
Our goal was to identify the factors with the strongest influence on the minimum lamina
cribrosa (LC) oxygen concentration as potentially indicative of conditions increasing hypoxia …

[HTML][HTML] Prevalence of common and rare ophthalmic findings in adults attending a medical survey institute

DL Prat, N Kapelushnik, O Zloto, A Leshno… - International …, 2024 - ncbi.nlm.nih.gov
Purpose To examine the ophthalmic data from a large database of people attending a
general medical survey institute, and to investigate ophthalmic findings of the eye and its …