Glaucoma: the retina and beyond
BM Davis, L Crawley, M Pahlitzsch, F Javaid… - Acta …, 2016 - Springer
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …
The role of lamina cribrosa tissue stiffness and fibrosis as fundamental biomechanical drivers of pathological glaucoma cupping
AA Hopkins, R Murphy, M Irnaten… - … of Physiology-Cell …, 2020 - journals.physiology.org
The primary biomechanical driver of pathological glaucomatous cupping remains unknown.
Finite element modeling indicates that stress and strain play key roles. In this article …
Finite element modeling indicates that stress and strain play key roles. In this article …
[HTML][HTML] Cerebrospinal fluid pressure: revisiting factors influencing optic nerve head biomechanics
Purpose: To model the sensitivity of the optic nerve head (ONH) biomechanical environment
to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery …
to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery …
Lamina cribrosa pore shape and size as predictors of neural tissue mechanical insult
AP Voorhees, NJ Jan, ME Austin… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: The purpose of this study was to determine how the architecture of the lamina
cribrosa (LC) microstructure, including the shape and size of the lamina pores, influences …
cribrosa (LC) microstructure, including the shape and size of the lamina pores, influences …
So-called lamina cribrosa defects may mitigate IOP-induced neural tissue insult
Purpose: The prevailing theory about the function of lamina cribrosa (LC) connective tissues
is that they provide structural support to adjacent neural tissues. Missing connective tissues …
is that they provide structural support to adjacent neural tissues. Missing connective tissues …
Role of radially aligned scleral collagen fibers in optic nerve head biomechanics
Collagen fibers organized circumferentially around the canal in the peripapillary sclera are
thought to provide biomechanical support to the sensitive tissues within the optic nerve head …
thought to provide biomechanical support to the sensitive tissues within the optic nerve head …
Quantification of material constants for a phenomenological constitutive model of porcine tricuspid valve leaflets for simulation applications
The tricuspid valve is a one-way valve on the pulmonary side of the heart, which prevents
backflow of blood during ventricular contractions. Development of computational models of …
backflow of blood during ventricular contractions. Development of computational models of …
Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell
Collagen is the main load-bearing component of cornea and sclera. When stretched, both of
these tissues exhibit a behavior known as collagen fiber recruitment. In recruitment, as the …
these tissues exhibit a behavior known as collagen fiber recruitment. In recruitment, as the …
Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa
Our goal was to identify the factors with the strongest influence on the minimum lamina
cribrosa (LC) oxygen concentration as potentially indicative of conditions increasing hypoxia …
cribrosa (LC) oxygen concentration as potentially indicative of conditions increasing hypoxia …
[HTML][HTML] Prevalence of common and rare ophthalmic findings in adults attending a medical survey institute
DL Prat, N Kapelushnik, O Zloto, A Leshno… - International …, 2024 - ncbi.nlm.nih.gov
Purpose To examine the ophthalmic data from a large database of people attending a
general medical survey institute, and to investigate ophthalmic findings of the eye and its …
general medical survey institute, and to investigate ophthalmic findings of the eye and its …