Ependymal tumors are rare CNS tumors and may occur at any age, but their proportion
among primary brain tumors is highest in children and young adults. Thus, the level of …

Abstract Purpose of Review To review state of art and relevant advances in the molecular
genetics and management of ependymomas of children and adults. Recent Findings …

Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior
fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further …

Spinal ependymal tumors form a histologically and molecularly heterogeneous group of
tumors with generally good prognosis. However, their treatment can be challenging if …

Pediatric neuro-oncology has undergone an exciting and dramatic transformation during the
past 5 years. This article summarizes data from collaborative group and institutional trials …

Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …

Understanding the biology that underlies histologically similar but molecularly distinct
subgroups of cancer has proven difficult because their defining genetic alterations are often …

Background Histopathological grading of ependymoma has been controversial with respect
to its reproducibility and clinical significance. In a 3-phase study, we reviewed the pathology …

YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the
molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 …

Background Ependymomas are rare CNS tumors. Previous studies describing the clinical
course of ependymoma patients were restricted to small sample sizes, often with patients at …