The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

The Genetic Basis for Cardiomyopathy: Cell Skip to Main Content Advertisement Cell This
journal offers authors two options (open access or subscription) to publish research This …

The mechanisms by which truncating mutations in MYBPC3 (encoding cardiac myosin-
binding protein C; cMyBPC) or myosin missense mutations cause hypercontractility and …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Hypertrophic cardiomyopathy (HCM), a relatively common disease, is diagnosed clinically
by unexplained cardiac hypertrophy and pathologically by myocyte hypertrophy, disarray …

Familial hypertrophic cardiomyopathy (FHC) is an inherited autosomal dominant disease
caused by mutations in sarcomeric proteins. Among these, mutations that affect myosin …

During the past 5 years there has been an increasing body of literature describing the roles
cardiac myosin binding protein C (cMyBP-C) phosphorylation play in regulating cardiac …

Inherited cardiomyopathies include hypertrophic cardiomyopathy, dilated cardiomyopathy,
arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, and …

Myosin binding protein-C (MyBP-C) is a thick filament–associated protein localized to the
crossbridge-containing C zones of striated muscle sarcomeres. The cardiac isoform is …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …