Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same
historically intransigent problem that has existed since the initial description of the disease in …

The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di
Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD).
PrLDs are low-complexity domains that possess a similar amino acid composition to prion …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor
nervous system. We show using multielectrode array and patch-clamp recordings that …

Early reports of cognitive and behavioural deficits in motor neuron disease might have been
overlooked initially, but the concept of a frontotemporal dementia-motor neuron disease …

Importance Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
of the motor nervous system. Clinical studies have demonstrated cortical and spinal motor …

Prions are self-templating protein conformers that are naturally transmitted between
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …

Abnormal intracellular protein aggregates comprise a key characteristic in most
neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and …

Hereditary amyotrophic lateral sclerosis (ALS) encompasses a group of genetic disorders
characterized by adult-onset loss of the lower and upper motor neuron systems, often with …