Saturated fatty acids in obesity-associated inflammation

H Zhou, CJ Urso, V Jadeja - Journal of inflammation research, 2020 - Taylor & Francis
Obesity is a major risk factor for the development of various pathological conditions
including insulin resistance, diabetes, cardiovascular diseases, and non-alcoholic fatty liver …

Placental mitochondrial function and structure in gestational disorders

O Holland, MD Nitert, LA Gallo, M Vejzovic, JJ Fisher… - Placenta, 2017 - Elsevier
The aetiology of many gestational disorders is still unknown. However, insufficient trans-
placental nutrient and oxygen transfer due to abnormal placentation is characteristic of …

Dihydromyricetin inhibits NLRP3 inflammasome‐dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells

Q Hu, T Zhang, L Yi, X Zhou, M Mi - Biofactors, 2018 - Wiley Online Library
Increasing evidence demonstrates that pyroptosis, pro‐inflammatory programmed cell
death, is linked to atherosclerosis; however, the underlying mechanisms remain to be …

[HTML][HTML] Inflammation and cardiovascular disease: the future

N Arnold, K Lechner, C Waldeyer… - European Cardiology …, 2021 - ncbi.nlm.nih.gov
Despite considerable advances in reducing the global burden of atherosclerotic
cardiovascular disease by targeting conventional risk factors, significant residual risk …

ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation

S Zheng, X Que, S Wang, Q Zhou, X Xing, L Chen… - Molecular cell, 2023 - cell.com
The nucleotide-binding domain (NBD), leucine-rich repeat (LRR), and pyrin domain (PYD)-
containing protein 3 (NLRP3) inflammasome is a critical mediator of the innate immune …

Inflammasomes: their role in normal and complicated pregnancies

N Gomez-Lopez, K Motomura, D Miller… - The Journal of …, 2019 - journals.aai.org
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …

Role of the NLRP3 inflammasome in preeclampsia

K Shirasuna, T Karasawa, M Takahashi - Frontiers in endocrinology, 2020 - frontiersin.org
Reproduction involves tightly regulated series of events and the immune system is involved
in an array of reproductive processes. Disruption of well-controlled immune functions leads …

SIRT1 alleviates LPS-induced IL-1β production by suppressing NLRP3 inflammasome activation and ROS production in trophoblasts

S Park, J Shin, J Bae, D Han, SR Park, J Shin, SK Lee… - Cells, 2020 - mdpi.com
Emerging evidence indicates that aberrant maternal inflammation is associated with several
pregnancy-related disorders such as preeclampsia, preterm birth, and intrauterine growth …

Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer

S Qiao, C Lv, Y Tao, Y Miao, Y Zhu, W Zhang, D Sun… - Cancer Letters, 2020 - Elsevier
Arctigenin, the major active constituent of Fructus Arctii, has been reported to inhibit the
growth of various tumors and alleviate colitis. This study aimed to prove the protective effect …

[HTML][HTML] Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches

JF Hebert, L Myatt - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Both obesity and gestational diabetes mellitus (GDM) lead to poor maternal and fetal
outcomes, including pregnancy complications, fetal growth issues, stillbirth, and …