Abstract Purpose of Review Over the last few years, the scientific community has made
significant progress in understanding the etiology of rheumatoid arthritis (RA). In this review …

Background Rheumatoid arthritis (RA) is the most common chronic autoimmune connective
tissue disease. However, early RA is difficult to diagnose due to the lack of effective …

Background & Aims Rheumatoid arthritis (RA) is a prototypic autoimmune disease causing
inflammatory polyarthritis that affects nearly 1% of the population. RA can lead to joint …

Objective Fibroblast‐like synoviocytes (FLSs) contribute to inflammation and joint damage in
rheumatoid arthritis (RA). However, the regulatory mechanisms of FLSs in relapse and …

Background Rheumatoid arthritis (RA) refers to an autoimmune rheumatic disease that
imposes a huge burden on patients and society. Early RA diagnosis is critical to preventing …

Objectives An interferon (IFN) gene signature (IGS) is present in approximately 50% of early,
treatment naive rheumatoid arthritis (eRA) patients where it has been shown to negatively …

Germinal center (GC) responses potentiate the generation of follicular regulatory T (TFR)
cells. However, the molecular cues driving TFR cell formation remain unknown. Here, we …

Dysregulated IL-1β and IL-6 responses have been implicated in the pathogenesis of severe
Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological …

The interferon gene signature (IGS) is derived from the expression of interferon-regulated
genes and is classically increased in response to type I interferon exposure. A raised whole …

Abstract Purpose of Review Type 1 interferons (IFN-I) are of increasing interest across a
wide range of autoimmune rheumatic diseases. Historically, research into their role in …