Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
In contrast to other respiratory viruses, children have less severe symptoms when infected
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …

Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Severe COVID-19 outcomes in pediatrics: An observational cohort analysis comparing Alpha, Delta, and Omicron variants

A Bahl, N Mielke, S Johnson, A Desai… - The Lancet Regional …, 2023 - thelancet.com
Objective COVID-19 can rarely lead to severe illness in pediatric patients. The aim of this
study was to determine if severe outcomes in pediatric COVID-19 have changed over the …

[HTML][HTML] Etiological, epidemiological, and clinical features of acute diarrhea in China

LP Wang, SX Zhou, X Wang, QB Lu, LS Shi… - Nature …, 2021 - nature.com
National-based prospective surveillance of all-age patients with acute diarrhea was
conducted in China between 2009‒2018. Here we report the etiological, epidemiological …

Coinfections and their molecular consequences in the porcine respiratory tract

G Saade, C Deblanc, J Bougon, C Marois-Créhan… - Veterinary …, 2020 - Springer
Understudied, coinfections are more frequent in pig farms than single infections. In pigs, the
term “Porcine Respiratory Disease Complex”(PRDC) is often used to describe coinfections …

Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire

EV Koonin, KS Makarova, YI Wolf… - Nature Reviews …, 2020 - nature.com
All cellular life forms are afflicted by diverse genetic parasites, including viruses and other
types of mobile genetic elements (MGEs), and have evolved multiple, diverse defence …

Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4+ T Cell Responses

EH Kim, TQ Nguyen, MAB Casel, R Rollon… - Journal of …, 2022 - Am Soc Microbiol
Given the current coronavirus disease 2019 (COVID-19) pandemic, coinfection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) is a …

Coinfection by severe acute respiratory syndrome coronavirus 2 and influenza A (H1N1) pdm09 virus enhances the severity of pneumonia in golden Syrian hamsters

AJ Zhang, ACY Lee, JFW Chan, F Liu… - Clinical infectious …, 2021 - academic.oup.com
Background Clinical outcomes of the interaction between the co-circulating pandemic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and seasonal influenza …

Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research

F Hufsky, K Lamkiewicz, A Almeida… - Briefings in …, 2021 - academic.oup.com
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of
the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of …

Host-directed antiviral therapy

N Kumar, S Sharma, R Kumar, BN Tripathi… - Clinical microbiology …, 2020 - Am Soc Microbiol
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …