Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Although serum from patients with Parkinson's disease contains elevated levels of
numerous pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether …

The Parkinson's disease factors PINK1 and parkin are strongly implicated in stress-induced
mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo. We …

It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

BACKGROUND Evolution generally trundles along by selecting for mutations or by
leveraging the new realms generated from chromosomal amplifications and the transfer of …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily
influenced by the genes associated with the disease. The α-synuclein-centric theory of …

Loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) or parkin genes, which
encode a mitochondrially localized serine/threonine kinase and a ubiquitin-protein ligase …

Maintaining mitochondrial health is essential for the survival and function of eukaryotic
organisms. Misfunctioning mitochondria activate stress-responsive pathways to restore …