Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Recently, click chemistry has provided important advances in biomedical research fields.
Particularly, copper-free click chemistry including strain-promoted azide–alkyne …

Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or
high pressure. However, copper‐free click chemistry has been shown to have favorable …

The reactions of organic azides and alkynes catalysed by copper species represent the
prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed …

Collagen is the most abundant structural protein of connective tissues including skin,
tendon, bone and cartilage in mammals. The complicated biosynthesis of nature collagen in …

Hydrogels, microgels and nanogels have emerged as versatile and viable platforms for
sustained protein release, targeted drug delivery, and tissue engineering due to excellent …

Despite enormous progress in the field of the synthetic chemistry involving, for example,
catalytic and combinatorial synthesis of a large libraries of compounds, multicomponent …

Click reactions have the potential to greatly facilitate the development of drug delivery
systems and biomaterials. These reactions proceed under mild conditions, give high yields …

Click chemistry is an efficient and chemoselective synthetic method for coupling molecular
fragments under mild reaction conditions. Since the advent in 2001 of methods to improve …