The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives
L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases
In this paper, the estabished and possible roles of CCK1 and CCK2 receptors in
gastrointestinal (GI) and metabolic diseases are reviewed and available results from human …
gastrointestinal (GI) and metabolic diseases are reviewed and available results from human …
Progress in developing cholecystokinin (CCK)/gastrin receptor ligands that have therapeutic potential
Gastrin and cholecystokinin (CCK) are two of the oldest hormones and within the past 15
years there has been an exponential increase in knowledge of their pharmacology, cell …
years there has been an exponential increase in knowledge of their pharmacology, cell …
Molecular mechanisms in therapy of acid-related diseases
JM Shin, O Vagin, K Munson, M Kidd, IM Modlin… - Cellular and molecular …, 2008 - Springer
Inhibition of gastric acid secretion is the mainstay of the treatment of gastroesophageal reflux
disease and peptic ulceration; therapies to inhibit acid are among the best-selling drugs …
disease and peptic ulceration; therapies to inhibit acid are among the best-selling drugs …
3D-QSAR modeling and molecular docking studies on a series of 2, 4, 5-trisubstituted imidazole derivatives as CK2 inhibitors
A Goudzal, A El Aissouq, H El Hamdani… - Journal of …, 2023 - Taylor & Francis
Protein case in kinase II alpha subunit (CK2) plays an imperative function in treating cancer
disease. Herein, we have performed a three-dimensional quantitative structure activity …
disease. Herein, we have performed a three-dimensional quantitative structure activity …
Nonpeptidic ligands for peptide-activated G protein-coupled receptors
JS Blakeney, RC Reid, GT Le, DP Fairlie - Chemical reviews, 2007 - ACS Publications
There are some 850 human G protein-coupled receptors (GPCRs) currently known
(http://bioinformatics2. biol. uoa. gr), making this the most abundant family of well …
(http://bioinformatics2. biol. uoa. gr), making this the most abundant family of well …
[HTML][HTML] Enantioselective N-Heterocyclic Carbene-Catalyzed Annulation Reactions with Imidazolidinones
EOB McCusker, KA Scheidt - Angewandte Chemie (International …, 2013 - ncbi.nlm.nih.gov
The development of efficient strategies for the stereoselective construction of privileged
heterocyclic systems is an important objective in chemical synthesis and pharmaceutical …
heterocyclic systems is an important objective in chemical synthesis and pharmaceutical …
[HTML][HTML] EGFR, HER2 target based molecular docking analysis, in vitro screening of 2, 4, 5-trisubstituted imidazole derivatives as potential anti-oxidant and cytotoxic …
In our endeavor towards the development of potent molecules for cancer diseases, we have
designed and synthesized a series of 2, 4, 5-trisubstituted imidazole derivatives (B1–B24) …
designed and synthesized a series of 2, 4, 5-trisubstituted imidazole derivatives (B1–B24) …
Scaffold Hopping with Molecular Field Points: Identification of a Cholecystokinin-2 (CCK2) Receptor Pharmacophore and Its Use in the Design of a Prototypical Series of …
CMR Low, IM Buck, T Cooke, JR Cushnir… - Journal of medicinal …, 2005 - ACS Publications
A new molecular modeling approach has been used to derive a pharmacophore of the
potent and selective cholecystokinin-2 (CCK2) receptor antagonist 5 (JB93182), based on …
potent and selective cholecystokinin-2 (CCK2) receptor antagonist 5 (JB93182), based on …
Application of 2,4,5‐tris(2‐pyridyl)imidazole as 'turn‐off' fluorescence sensor for Cu(II) and Hg(II) ions and in vitro cell imaging
Abstract The 2, 4, 5‐tris (2‐pyridyl) imidazole (L) molecule has been evaluated as a probe
for dual sensing of Hg2+ and Cu2+ ions in EtOH/HEPES buffer medium (5 mM, pH= 7.34, 1 …
for dual sensing of Hg2+ and Cu2+ ions in EtOH/HEPES buffer medium (5 mM, pH= 7.34, 1 …