Amide bond construction has garnered significant interest in recent decades due to amides
being one of the most prevalent functional groups among bioactive molecules. Out of the …

This Minireview presents recent important homogenous aerobic oxidative reactions which
are assisted by electron transfer mediators (ETMs). Compared with direct oxidation by …

The “magic methyl” effect describes the change in potency, selectivity, and/or metabolic
stability of a drug candidate associated with addition of a single methyl group. We report a …

In the micelle of PS-750-M, the presence of 3° amides from the surfactant proline linker
mimics dimethylformamide, dimethylacetamide, and N-methyl-2-pyrrolidone. The resultant …

An electrochemical amidation of benzoyl hydrazine/carbazate and primary/secondary amine
as coupling partners via concomitant cleavage and formation of C (sp2)–N bonds has been …

Amide is essential in biologically active compounds, synthetic materials, and building
blocks. However, conventional amide production relies on energy-intensive consumption …

The successive cleavage and functionalization of C–C bonds in alcohols has become a
rapidly growing field for the discovery of new transformations. However, achieving it in a …

Organocatalysis is widely recognized as a key synthetic methodology in organic chemistry. It
allows chemists to avoid the use of precious and (or) toxic metals by taking advantage of the …

The current existing methods for the amide bond synthesis via acceptorless
dehydrogenative coupling of amines and alcohols all require high reaction temperatures for …

The catalytic synthesis of amides directly from primary alcohols and amines represents an
atom‐economical and environmentally benign methodology, which produces H2 as the sole …