The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

The worldwide impact of the ongoing COVID-19 pandemic on public health has made
imperative the discovery and development of direct-acting antivirals aimed at targeting viral …

COVID-19 caused by SARS-CoV-2 in late 2019 is still threatening global human health.
Although some vaccines and drugs are available in the market, controlling the spread of the …

The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …

The reactive functionalities of drugs that engage in covalent interactions with the
enzyme/receptor residue in either a reversible or an irreversible manner are …

As the COVID-19 pathogen, SARS-CoV-2 relies on its main protease (MPro) for
pathogenesis and replication. During crystallographic analyses of MPro crystals that were …

Over 110 years after the first formal description of Chagas disease, the trypanocidal drugs
thus far available have limited efficacy and several side effects. This encourages the search …

The advent of SARS-CoV-2, the causative agent of COVID-19, and its worldwide impact on
global health, have provided the impetus for the development of effective countermeasures …

Bisphenol A (BPA) is an environmental hormone with substantial physiological toxicity to the
human body. Three electron-withdrawing derivatives of BPA are synthesized in this study to …