Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this complex disorder of the …

The processing of amyloid precursor protein (APP) generates amyloid-β (Aβ) peptides 1–40
and 1–42. The latter is neurotoxic and its accumulation results in amyloid fibril formation and …

Background. Senile systemic amyloidosis (SSA) is characterized by deposition of wild‐type
transthyretin (TTR)‐based amyloid in parenchymal organs in elderly individuals. Previously …

Amyloid β peptides are bound rapidly in the plasma complicating an accurate assessment of
their in vivo abundance by immunoassay procedures. The extent of Aβ immunoassay …

Background: Medial temporal lobe atrophy (MTA) is a sensitive radiologic marker for
Alzheimer disease (AD) and associated with cognitive impairment. The value of MTA in the …

Mental actions are based on the dynamic organization of neuronal networks. In particular,
phylogenetically young brain areas (eg, cortical associative circuits) involved in the …

Elevated plasma total homocysteine is associated with increased risk of
dementia/Alzheimer's disease, but underlying pathophysiological mechanisms are not fully …

Perspective tein, four are located in the luminal loop between predicted transmembrane
domains one and two, two are in the large cytoplasmic loop between predicted …

The Decade of the Brain—the 1990s—was a time of gains in our knowledge of the
molecular and genetic basis of Alzheimer's disease (AD). 1-4 The momentum of discovery …

According to a generally accepted concept Lewy-related pathology (LRP) follows
hierarchical caudo-rostral progression. LRP is also frequently present concomitantly with …