Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells

AC Liberman, ML Budziñski, C Sokn… - Frontiers in …, 2018 - frontiersin.org
Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune
response and have been used since decades to treat various inflammatory and autoimmune …

The many faces of FKBP51

A Hähle, S Merz, C Meyners, F Hausch - Biomolecules, 2019 - mdpi.com
The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress
responses in mammals and as a potential therapeutic target for stress-related disorders …

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk

AS Zannas, M Jia, K Hafner… - Proceedings of the …, 2019 - National Acad Sciences
Aging and psychosocial stress are associated with increased inflammation and disease risk,
but the underlying molecular mechanisms are unclear. Because both aging and stress are …

[HTML][HTML] The nuclear receptor field: a historical overview and future challenges

GI Mazaira, NR Zgajnar, CM Lotufo… - Nuclear receptor …, 2018 - ncbi.nlm.nih.gov
In this article we summarize the birth of the field of nuclear receptors, the discovery of
untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of …

FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention

S Annett, G Moore, T Robson - Pharmacology & Therapeutics, 2020 - Elsevier
FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …

Biological actions of the Hsp90-binding immunophilins FKBP51 and FKBP52

NR Zgajnar, SA De Leo, CM Lotufo, AG Erlejman… - Biomolecules, 2019 - mdpi.com
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-
isomerase domain. High molecular weight immunophilins are characterized by the …

HSP90AB1: Helping the good and the bad

M Haase, G Fitze - Gene, 2016 - Elsevier
HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as
HSP90beta, is a member of the large family of HSPs which function as molecular …

Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad

M Bekhbat, SA Rowson, GN Neigh - Frontiers in neuroendocrinology, 2017 - Elsevier
Mutual regulation and balance between the endocrine and immune systems facilitate an
organism's stress response and are impaired following chronic stress or prolonged immune …

IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA

Q Zheng, D Wang, R Lin, Q Lv, W Wang - Frontiers in immunology, 2022 - frontiersin.org
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic of severe coronavirus disease 2019 (COVID-19). Staphylococcus aureus is …

Inhibition of FKBP51 induces stress resilience and alters hippocampal neurogenesis

MG Codagnone, N Kara, A Ratsika, BR Levone… - Molecular …, 2022 - nature.com
Stress-related psychiatric disorders such as depression are among the leading causes of
morbidity and mortality. Considering that many individuals fail to respond to currently …