Fezolinetant in the treatment of vasomotor symptoms associated with menopause

H Depypere, C Lademacher, E Siddiqui… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Although international clinical practice guidelines recognize a continued role
for menopausal hormone therapy (HT), particularly for symptomatic women< 60 years of age …

Adrenal medulla development and medullary-cortical interactions

N Bechmann, I Berger, SR Bornstein… - Molecular and Cellular …, 2021 - Elsevier
The mammalian adrenal gland is composed of two distinct tissue types in a bidirectional
connection, the catecholamine-producing medulla derived from the neural crest and the …

Aldosterone breakthrough from a pharmacological perspective

M Mogi - Hypertension Research, 2022 - nature.com
Aldosterone (Aldo) breakthrough is a well-known phenomenon that occurs in patients with
long-term renin-angiotensin aldosterone system (RAAS) blockade using inhibitors of renin …

[HTML][HTML] COVID-19 usurps host regulatory networks

CS Curran, DR Rivera, JB Kopp - Frontiers in Pharmacology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes
coronavirus disease 2019 (COVID-19). SARS-CoV-2 binds the angiotensin-converting …

Electronic drugs: spatial and temporal medical treatment of human diseases

C Won, C Kwon, K Park, J Seo, T Lee - Advanced Materials, 2021 - Wiley Online Library
Recent advances in diagnostics and medicines emphasize the spatial and temporal aspects
of monitoring and treating diseases. However, conventional therapeutics, including oral …

Substance P‐induced lung inflammation in mice is mast cell dependent

N Wang, J Wang, Y Zhang, S Hu… - Clinical & …, 2022 - Wiley Online Library
Background Allergic asthma is a common inflammatory lung disease and a major health
problem worldwide. Mast cells (MCs) play a key role in the early‐stage pathophysiology of …

Peptidergic G protein–coupled receptor regulation of adrenal function: bench to bedside and back

L Lenzini, B Caroccia, TM Seccia… - Endocrine …, 2022 - academic.oup.com
An altered secretion of adrenocortical and adrenomedullary hormones plays a role in the
clinical syndromes of primary aldosteronism (PA), Cushing, and pheochromocytoma …

Aldosterone breakthrough as a clue to the physiological importance of paracrine regulation of aldosterone secretion

AG Lopez, E Louiset, H Lefebvre - Hypertension Research, 2022 - nature.com
Aldosterone breakthrough is usually defined as an elevation of plasma aldosterone levels
(PALs) during chronic administration of angiotensin-converting enzyme inhibitors (ACEis) …

Vascular and hormonal interactions in the adrenal gland

AB Abdellatif, FL Fernandes-Rosa… - Frontiers in …, 2022 - frontiersin.org
Primary aldosteronism is the most common form of secondary arterial hypertension, due to
excessive aldosterone production from the adrenal gland. Although somatic mutations have …

Colocalization of wnt/β-catenin and ACTH signaling pathways and paracrine regulation in aldosterone-producing adenoma

K De Sousa, AB Abdellatif… - The Journal of …, 2022 - academic.oup.com
Abstract Context Aldosterone-producing adenomas (APAs) are a common cause of primary
aldosteronism (PA). Despite the discovery of somatic mutations in APA and the …