The pathophysiology of epilepsy has been historically grounded on hyperexcitability
attributed to the oversimplified imbalance between excitation (E) and inhibition (I) in the …

Alterations in neocortical GABAergic interneurons (INs) have been affiliated with
neuropsychiatric diseases, including schizophrenia (SZ). Significant progress has been …

Inhibitory interneurons are crucial to brain function and their dysfunction is implicated in
neuropsychiatric conditions. Emerging evidence indicates that cholecystokinin (CCK) …

The combination of optical tissue transparency with immunofluorescence allows the
molecular characterization of biological tissues in 3D. However, adult human organs are …

Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine
exposure modifies the excitability and functional interactions between neurons, while the …

Single-unit recordings performed in temporal lobe epilepsy patients and in models of
temporal lobe seizures have shown that interneurons are active at focal seizure onset. We …

The neurobiological bases of mood instability are poorly understood. Neuronal network
alterations and neurometabolic abnormalities have been implicated in the pathophysiology …

Somatostatin cells are frequently described as a major population of GABAergic neurons in
the cerebral cortex. In this study, we performed a comprehensive analysis of their molecular …

Cholecystokinin (CCK), the most abundant brain neuropeptide, is involved in relevant
behavioral functions like memory, cognition, and reward through its interactions with the …

FOXG1 syndrome is a severe encephalopathy that exhibit intellectual disability, emotional
disorder, and limited social communication. To elucidate the contribution of somatostatin …