Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Cisplatin and other platinum compounds have had a huge impact in the treatment of cancers
and are applied in the majority of anticancer chemotherapeutic regimens. The success of …

A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially
superoxide and hydroxyl radical) and high-energy oxidants (such as peroxynitrite) as …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by death of motor neurons leading to muscle wasting, paralysis, and death …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Paraquat, a quarternary nitrogen herbicide, is a highly toxic compound for humans and
animals and many cases of acute poisoning and death have been reported over the past …

Accumulated evidence has shown that reactive oxygen species (ROS) are important
mediators of cell signaling events such as inflammatory reactions (superoxide) and the …

Paradoxically, reactive oxygen species (ROS) can promote normal cellular proliferation and
carcinogenesis, and can also induce apoptosis of tumor cells. In this report, we study the …

Mitochondrial oxidative stress and dysfunction are contributing factors to various
neurological disorders. Recently, there has been increasing evidence supporting the …

As the number of industrial applications for proteins continues to expand, the exploitation of
protein engineering becomes critical. It is predicted that protein engineering can generate …