Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
From carbohydrate leads to glycomimetic drugs
B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …
and as structural building blocks, they are fundamental constituents of every cell surface …
Nanoparticle-based drug delivery to the vagina: a review
Vaginal drug administration can improve prophylaxis and treatment of many conditions
affecting the female reproductive tract, including sexually transmitted diseases, fungal and …
affecting the female reproductive tract, including sexually transmitted diseases, fungal and …
Targeting C-type lectin receptors with multivalent carbohydrate ligands
B Lepenies, J Lee, S Sonkaria - Advanced drug delivery reviews, 2013 - Elsevier
C-type lectin receptors (CLRs) represent a large receptor family including collectins,
selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous …
selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous …
Gold Manno‐Glyconanoparticles: Multivalent Systems to Block HIV‐1 gp120 Binding to the Lectin DC‐SIGN
The HIV envelope glycoprotein gp120 takes advantage of the high‐mannose clusters on its
surface to target the C‐type lectin dendritic cell‐specific intracellular adhesion molecule‐3 …
surface to target the C‐type lectin dendritic cell‐specific intracellular adhesion molecule‐3 …
Glycofullerenes inhibit viral infection
J Luczkowiak, A Munoz, M Sanchez-Navarro… - …, 2013 - ACS Publications
Water-soluble glycofullerenes based on a hexakis-adduct of [60] fullerene with an
octahedral addition pattern are very attractive compounds providing a spherical presentation …
octahedral addition pattern are very attractive compounds providing a spherical presentation …
Nanotechnology and the treatment of HIV infection
Suboptimal adherence, toxicity, drug resistance and viral reservoirs make the lifelong
treatment of HIV infection challenging. The emerging field of nanotechnology may play an …
treatment of HIV infection challenging. The emerging field of nanotechnology may play an …
Mannosylated G(0) Dendrimers with Nanomolar Affinities to Escherichia coli FimH
M Touaibia, A Wellens, TC Shiao… - ChemMedChem …, 2007 - Wiley Online Library
Pentaerythritol and bis‐pentaerythritol scaffolds were used for the preparation of first
generation glycodendrimers bearing aryl α‐d‐mannopyranoside residues assembled using …
generation glycodendrimers bearing aryl α‐d‐mannopyranoside residues assembled using …
A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus
N Varga, I Sutkeviciute, R Ribeiro-Viana, A Berzi… - Biomaterials, 2014 - Elsevier
Abstract DC-SIGN is a C-type lectin receptor on antigen presenting cells (dendritic cells)
which has an important role in some viral infection, notably by HIV and Dengue virus (DV) …
which has an important role in some viral infection, notably by HIV and Dengue virus (DV) …
Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo
KC Sheng, M Kalkanidis, DS Pouniotis… - European Journal of …, 2008 - Wiley Online Library
Antigen mannosylation has been shown to be an effective approach to potentiate antigen
immunogenicity, due to the enhanced antigen uptake and presentation by APC. To …
immunogenicity, due to the enhanced antigen uptake and presentation by APC. To …