Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands

S Cecioni, A Imberty, S Vidal - Chemical reviews, 2015 - ACS Publications
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

From carbohydrate leads to glycomimetic drugs

B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Nanoparticle-based drug delivery to the vagina: a review

LM Ensign, R Cone, J Hanes - Journal of Controlled Release, 2014 - Elsevier
Vaginal drug administration can improve prophylaxis and treatment of many conditions
affecting the female reproductive tract, including sexually transmitted diseases, fungal and …

Targeting C-type lectin receptors with multivalent carbohydrate ligands

B Lepenies, J Lee, S Sonkaria - Advanced drug delivery reviews, 2013 - Elsevier
C-type lectin receptors (CLRs) represent a large receptor family including collectins,
selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous …

Gold Manno‐Glyconanoparticles: Multivalent Systems to Block HIV‐1 gp120 Binding to the Lectin DC‐SIGN

O Martínez‐Ávila, K Hijazi, M Marradi… - … A European Journal, 2009 - Wiley Online Library
The HIV envelope glycoprotein gp120 takes advantage of the high‐mannose clusters on its
surface to target the C‐type lectin dendritic cell‐specific intracellular adhesion molecule‐3 …

Glycofullerenes inhibit viral infection

J Luczkowiak, A Munoz, M Sanchez-Navarro… - …, 2013 - ACS Publications
Water-soluble glycofullerenes based on a hexakis-adduct of [60] fullerene with an
octahedral addition pattern are very attractive compounds providing a spherical presentation …

Nanotechnology and the treatment of HIV infection

R Parboosing, GEM Maguire, P Govender, HG Kruger - Viruses, 2012 - mdpi.com
Suboptimal adherence, toxicity, drug resistance and viral reservoirs make the lifelong
treatment of HIV infection challenging. The emerging field of nanotechnology may play an …

Mannosylated G(0) Dendrimers with Nanomolar Affinities to Escherichia coli FimH

M Touaibia, A Wellens, TC Shiao… - ChemMedChem …, 2007 - Wiley Online Library
Pentaerythritol and bis‐pentaerythritol scaffolds were used for the preparation of first
generation glycodendrimers bearing aryl α‐d‐mannopyranoside residues assembled using …

A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

N Varga, I Sutkeviciute, R Ribeiro-Viana, A Berzi… - Biomaterials, 2014 - Elsevier
Abstract DC-SIGN is a C-type lectin receptor on antigen presenting cells (dendritic cells)
which has an important role in some viral infection, notably by HIV and Dengue virus (DV) …

Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo

KC Sheng, M Kalkanidis, DS Pouniotis… - European Journal of …, 2008 - Wiley Online Library
Antigen mannosylation has been shown to be an effective approach to potentiate antigen
immunogenicity, due to the enhanced antigen uptake and presentation by APC. To …