In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …

Throughout evolution, organisms have developed means to contain wounds by
simultaneously limiting bleeding and eliminating pathogens and damaged host cells via the …

Complement and coagulation are evolutionarily related proteolytic cascades in the blood
that are critical for effecting an appropriate innate response to injury that limits bleeding and …

Inter-α-inhibitor heavy chain 4 (ITIH4) is a poorly characterized plasma protein that is
proteolytically processed in multiple pathological conditions. However, no biological function …

Thyroid hormones critically modulate body homeostasis and haemostasis by regulating
energy and metabolism. Previous studies have focused on individual pathways or proteins …

Atherosclerosis remains a ubiquitous and serious threat to human health. The initial
formation of the atherosclerotic lesion (atheroma) is driven by pro-inflammatory signaling …

The human complement pathway plays a pivotal role in immune defence, homeostasis, and
autoimmunity regulation, and complement-based therapeutics have emerged as promising …

Background Epigenetic aberrations play a central role in the pathophysiology of acute
myeloid leukemia (AML). It has been shown that molecular signatures based on DNA …

To sustain life in environments that are fraught with risks of life-threatening injury, organisms
have developed innate protective strategies such that the response to wounds is rapid and …

The mannose-binding lectin associated-protease-3 (MASP-3) is a member of the lectin
pathway of the complement system, a key component of human innate and active immunity …