Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management

SYC Tong, JS Davis, E Eichenberger… - Clinical microbiology …, 2015 - Am Soc Microbiol
Staphylococcus aureus is a major human pathogen that causes a wide range of clinical
infections. It is a leading cause of bacteremia and infective endocarditis as well as …

Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm‐associated infections

S Cascioferro, D Carbone, B Parrino… - …, 2021 - Wiley Online Library
Methicillin‐resistant Staphylococcus aureus (MRSA) has emerged as one of the leading
causes of persistent human infections. This pathogen is widespread and is able to colonize …

Staphylococcal biofilms: Challenges and novel therapeutic perspectives

C Kranjec, D Morales Angeles, M Torrissen Mårli… - Antibiotics, 2021 - mdpi.com
Staphylococci, like Staphylococcus aureus and S. epidermidis, are common colonizers of
the human microbiota. While being harmless in many cases, many virulence factors result in …

Staphylococcus aureus biofilms: Properties, regulation, and roles in human disease

NK Archer, MJ Mazaitis, JW Costerton, JG Leid… - Virulence, 2011 - Taylor & Francis
Increasing attention has been focused on understanding bacterial biofilms and this growth
modality's relation to human disease. In this review we explore the genetic regulation and …

Biomaterials approaches to treating implant-associated osteomyelitis

JA Inzana, EM Schwarz, SL Kates, HA Awad - Biomaterials, 2016 - Elsevier
Orthopaedic devices are the most common surgical devices associated with implant-related
infections and Staphylococcus aureus (S. aureus) is the most common causative pathogen …

Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo

LR Thurlow, ML Hanke, T Fritz, A Angle… - The Journal of …, 2011 - journals.aai.org
Biofilms are complex communities of bacteria encased in a matrix composed primarily of
polysaccharides, extracellular DNA, and protein. Staphylococcus aureus can form biofilm …

Differential Roles of Poly-N-Acetylglucosamine Surface Polysaccharide and Extracellular DNA in Staphylococcus aureus and Staphylococcus epidermidis Biofilms

EA Izano, MA Amarante, WB Kher… - Applied and …, 2008 - Am Soc Microbiol
Staphylococcus aureus and Staphylococcus epidermidis are major human pathogens of
increasing importance due to the dissemination of antibiotic-resistant strains. Evidence …

[PDF][PDF] Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity

K Plata, A Rosato, G Węgrzyn - Acta Biochimica Polonica, 2009 - bibliotekanauki.pl
Although it is estimated that 20-30% of the general human population are carriers of
Staphylococcus aureus, this bacterium is one of the most important etiological agents …

Osteomyelitis and the role of biofilms in chronic infection

RA Brady, JG Leid, JH Calhoun… - FEMS Immunology & …, 2008 - academic.oup.com
Understanding the mechanisms implicated in the initial attachment, development, and
maturation of a biofilm phenotype are of tremendous importance for their effect on the …

From Clinical Microbiology to Infection Pathogenesis: How Daring To Be Different Works for Staphylococcus lugdunensis

KL Frank, JL Del Pozo, R Patel - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Staphylococcus lugdunensis has gained recognition as an atypically virulent pathogen with
a unique microbiological and clinical profile. S. lugdunensis is coagulase negative due to …