Intrahepatic cholestasis of pregnancy is a common disorder of pregnancy manifested by
pruritus and elevated bile acids. The etiology of cholestasis is poorly understood and …

Background Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of
pregnancy, yet its largest trial detected minimal benefit for a composite outcome (stillbirth …

Background Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and
increased serum bile acid concentrations, is associated with increased rates of stillbirth …

Intrahepatic cholestasis of pregnancy (ICP) is the most common hepatic disorder related to
pregnancy in women. It usually develops within the third trimester of pregnancy and …

This first Practice Guidance on Reproductive Health from the American Association for the
Study of Liver Diseases (AASLD) is intended to be a comprehensive reference on …

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific liver disease. The
maternal symptoms are characterized by skin pruritus and elevated bile acids, causing …

Bile acids (BAs) are key molecules in generating bile flow, which is an essential function of
the liver. In the last decades, there have been great advances in the understanding of BA …

Pruritus in pregnancy is a common and burdensome symptom that may be a first sign of a
pregnancy-specific pruritic disease (atopic eruption of pregnancy, polymorphic eruption of …

BACKGROUND The placenta is the active interface between mother and foetus, bearing the
molecular marks of rapid development and exposures in utero. The placenta is routinely …

Background Previous studies have shown that intrahepatic cholestasis of pregnancy (ICP) is
associated with an increased incidence of adverse perinatal outcomes, and this supports the …