Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

Mitochondria are multifaceted organelles with key roles in anabolic and catabolic
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …

Perilipins are abundant lipid droplet (LD) proteins present in all metazoans and also in
Amoebozoa and fungi. Humans express five perilipins, which share a similar domain …

Background and aim The excessive accumulation of lipid droplets (LDs) is a defining
characteristic of nonalcoholic fatty liver disease (NAFLD). The interaction between LDs and …

Recent studies in brown adipose tissue (BAT) described a unique subpopulation of
mitochondria bound to lipid droplets (LDs), which were termed PeriDroplet Mitochondria …

Contact sites between lipid droplets and other organelles are essential for cellular lipid and
energy homeostasis upon metabolic demands. Detection of these contact sites at the …

Endoplasmic reticulum (ER) is an essential organelle involved in vesicular transport,
calcium handling, protein synthesis and folding, and lipid biosynthesis and metabolism. ER …

The unique architecture of the liver allows for spatial compartmentalization of its functions,
also known as liver zonation. In contrast to organelles and cells, this compartment is devoid …

Hepatic steatosis, the buildup of neutral lipids in lipid droplets (LDs), is commonly referred to
as metabolic dysfunction-associated steatotic liver disease (MASLD) when alcohol or viral …

Electron microscopy (EM), in its various flavors, has significantly contributed to our
understanding of lipid droplets (LD) as central organelles in cellular metabolism. For …