Antenatal corticosteroids: a reappraisal of the drug formulation and dose
We review the history of antenatal corticosteroid therapy (ACS) and present recent
experimental data to demonstrate that this, one of the pillars of perinatal care, has been …
experimental data to demonstrate that this, one of the pillars of perinatal care, has been …
The hypothalamic-pituitary-adrenal axis and the fetus
A Morsi, D DeFranco, SF Witchel - Hormone research in paediatrics, 2018 - karger.com
Glucocorticoids (GCs), cortisol in humans, influence multiple essential maturational events
during gestation. In the human fetus, fetal hypothalamic-pituitary-adrenal (HPA) axis …
during gestation. In the human fetus, fetal hypothalamic-pituitary-adrenal (HPA) axis …
Antenatal corticosteroids: an assessment of anticipated benefits and potential risks
AH Jobe, RL Goldenberg - American journal of obstetrics and gynecology, 2018 - Elsevier
Antenatal corticosteroids are standard of care for pregnancies at risk of preterm delivery
between 24-34 weeks' gestational age. Recent trials demonstrate modest benefits from …
between 24-34 weeks' gestational age. Recent trials demonstrate modest benefits from …
Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind …
T Schmitz, M Doret-Dion, L Sentilhes, O Parant… - The Lancet, 2022 - thelancet.com
Background Antenatal betamethasone is recommended before preterm delivery to
accelerate fetal lung maturation. However, reports of growth and neurodevelopmental dose …
accelerate fetal lung maturation. However, reports of growth and neurodevelopmental dose …
Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation
Background Antenatal steroid therapy for fetal lung maturation is routinely administered to
women at risk of preterm delivery. There is strong evidence to demonstrate benefit from …
women at risk of preterm delivery. There is strong evidence to demonstrate benefit from …
Optimizing antenatal corticosteroid therapy
MW Kemp, AF Schmidt, AH Jobe - Seminars in Fetal and Neonatal …, 2019 - Elsevier
Abstract Treatment with antenatal corticosteroids (ACS) is standard of care for women at risk
of preterm birth between 24 and 34 weeks' gestation. ACS are increasingly used for other …
of preterm birth between 24 and 34 weeks' gestation. ACS are increasingly used for other …
The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy
Background Antenatal corticosteroids are among the most important and widely used
interventions to improve outcomes for preterm infants. Antenatal corticosteroid dosing …
interventions to improve outcomes for preterm infants. Antenatal corticosteroid dosing …
Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in …
T Takahashi, EL Fee, Y Takahashi, M Saito… - American journal of …, 2022 - Elsevier
Background Antenatal corticosteroid therapy is a standard of care for women at imminent
risk of preterm labor. However, the optimal (maximum benefit and minimal risk of side …
risk of preterm labor. However, the optimal (maximum benefit and minimal risk of side …
[HTML][HTML] Prenatal inflammation enhances antenatal corticosteroid–induced fetal lung maturation
Respiratory complications are the major cause of morbidity and mortality among preterm
infants, which is partially prevented by the administration of antenatal corticosteroids (ACS) …
infants, which is partially prevented by the administration of antenatal corticosteroids (ACS) …
A comparison of 2 doses of antenatal dexamethasone for the prevention of respiratory distress syndrome: an open-label, noninferiority, pragmatic randomized trial
S Chawanpaiboon, R Chukaew, J Pooliam - American Journal of …, 2024 - Elsevier
Background Antenatal corticosteroids have been used for the prevention of respiratory
complications, intraventricular hemorrhage, necrotizing enterocolitis, and other adverse …
complications, intraventricular hemorrhage, necrotizing enterocolitis, and other adverse …