Since wild-type p53 is central for maintaining genomic stability and preventing oncogenesis,
its coding gene TP53 is highly mutated in~ 50% of human cancers, and its activity is almost …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

It is poorly understood how a single protein, p53, can be responsive to so many stress
signals and orchestrates very diverse cell responses to maintain/restore cell/tissue functions …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Through novel methodologies, including both basic and clinical research, progress has
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …

The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …

Glioblastoma (GB) is the most common and devastating form of brain cancer. Despite
conventional treatments, progression or recurrences are systematic. In recent years …

p53, first described four decades ago, is now established as a master regulator of cellular
stress response, the “guardian of the genome”. p53 contributes to biological robustness by …

The tumour suppressor p53 is activated following genotoxic stress and regulates the
expression of target genes involved in the DNA damage response (DDR). The discovery that …

Metastasis is one of the most challenging issues in cancer patient management, and
effective therapies to specifically target disease progression are missing, emphasizing the …