Myofibroblasts play an important role in fibrogenesis. Hepatic stellate cells are the main
precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which …

Chronic liver diseases represent a global health problem due to their high prevalence
worldwide and the limited available curative treatment options. They can result from various …

Nanopartikel adalah partikel berukuran 1-100 nanometer. Nanopartikel bertujuan untuk
mengatasi kelarutan zat aktif yang sukar larut, memperbaiki bioavailabilitas yang buruk …

Many serious liver diseases affecting millions of people world-wide cannot be treated
despite many efforts which warrants a search for new therapeutic strategies. Potent drugs …

Teknologi nanopartikel saat ini telah menjadi tren baru dalam pengembangan sistem
penghantaran obat. Partikel atau globul pada skala nanometer memiliki sifat fisik yang khas …

The activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-
producing myofibroblasts (MFBs) are central events in hepatic fibrogenesis. These …

The major concern of pharmacology about cytokines has originated from plentiful data
showing association between gross changes in their production and pathophysiological …

The liver is the largest internal organ in mammals and is involved in metabolism,
detoxification, synthesis of proteins and lipids, secretion of cytokines and growth factors and …

Therapeutic proteins (TPs) are a diverse drug class that include monoclonal antibodies
(mAbs), recombinantly expressed enzymes, hormones and growth factors, cytokines (eg …

Age-related changes in liver function have a significant impact on systemic aging and
susceptibility to age-related diseases. Nutrient sensing pathways have emerged as …