HFIP in organic synthesis
HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …
The core lipocalin, bovine β-lactoglobulin
L Sawyer, G Kontopidis - Biochimica et Biophysica Acta (BBA)-Protein …, 2000 - Elsevier
The lipocalin family became established shortly after the structural similarity was noted
between plasma retinol binding protein and the bovine milk protein, β-lactoglobulin. During …
between plasma retinol binding protein and the bovine milk protein, β-lactoglobulin. During …
Clustering of fluorine-substituted alcohols as a factor responsible for their marked effects on proteins and peptides
DP Hong, M Hoshino, R Kuboi… - Journal of the American …, 1999 - ACS Publications
Among various alcohols, those substituted with fluorine, such as 2, 2, 2-trifluoroethanol
(TFE) or 3, 3, 3, 3 ', 3 ', 3 '-hexafluoro-2-propanol (HFIP), have a marked potential to induce …
(TFE) or 3, 3, 3, 3 ', 3 ', 3 '-hexafluoro-2-propanol (HFIP), have a marked potential to induce …
Molecular confinement influences protein structure and enhances thermal protein stability
DK Eggers, JS Valentine - Protein Science, 2001 - Wiley Online Library
The sol‐gel method of encapsulating proteins in a silica matrix was investigated as a
potential experimental system for testing the effects of molecular confinement on the …
potential experimental system for testing the effects of molecular confinement on the …
Mechanical properties of single electrospun collagen type I fibers
L Yang, CFC Fitié, KO Van Der Werf, ML Bennink… - Biomaterials, 2008 - Elsevier
The mechanical properties of single electrospun collagen fibers were investigated using
scanning mode bending tests performed with an AFM. Electrospun collagen fibers with …
scanning mode bending tests performed with an AFM. Electrospun collagen fibers with …
Challenges and perspectives in chemical synthesis of highly hydrophobic peptides
LK Mueller, AC Baumruck, H Zhdanova… - … in Bioengineering and …, 2020 - frontiersin.org
Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …
peptides and proteins. Applying the method on hydrophilic structures is usually without …
Hexafluoroisopropanol as a Bioconjugation Medium of Ultrafast, Tryptophan-Selective Catalysis
M Nuruzzaman, BM Colella, CP Uzoewulu… - Journal of the …, 2024 - ACS Publications
The past decade has seen a remarkable growth in the number of bioconjugation techniques
in chemistry, biology, material science, and biomedical fields. A core design element in …
in chemistry, biology, material science, and biomedical fields. A core design element in …
Crowding and hydration effects on protein conformation: a study with sol-gel encapsulated proteins
DK Eggers, JS Valentine - Journal of molecular biology, 2001 - Elsevier
We are developing an experimental system for testing the effects of macromolecular
crowding and molecular confinement on protein structure. In the present study, solvent …
crowding and molecular confinement on protein structure. In the present study, solvent …
Group additive contributions to the alcohol-induced α-helix formation of melittin: implication for the mechanism of the alcohol effects on proteins
Detailed analysis of the effects of alcohols on proteins and peptides is important because of
its wide range of applications in many fields. Whereas melittin, a major component of …
its wide range of applications in many fields. Whereas melittin, a major component of …
Folding amphipathic helices into membranes: amphiphilicity trumps hydrophobicity
M Fernández-Vidal, S Jayasinghe, AS Ladokhin… - Journal of molecular …, 2007 - Elsevier
High amphiphilicity is a hallmark of interfacial helices in membrane proteins and membrane-
active peptides, such as toxins and antimicrobial peptides. Although there is general …
active peptides, such as toxins and antimicrobial peptides. Although there is general …