Design, synthesis, and antiproliferative screening of new quinoline derivatives bearing a cis-vinyl triamide motif as apoptosis activators and EGFR-TK inhibitors
In this work, a congeneric set of quinoline-tethered cis-vinyl triamide hybrids was prepared
and evaluated as EGFR tyrosine kinase inhibitors for the management of breast cancer. All …
and evaluated as EGFR tyrosine kinase inhibitors for the management of breast cancer. All …
Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 …
HM Abd El-Lateef, TH Alharbi, E Fayad… - Journal of Molecular …, 2025 - Elsevier
A new set of quinolin-4-ylcarbonylhydrazine derivatives 7a-i and 9a, b bearing 3-arylacryloyl
moiety has been synthesized and investigated for their potential anticancer activity. The …
moiety has been synthesized and investigated for their potential anticancer activity. The …
Synthesis and biological research of new imidazolone-sulphonamide-pyrimidine hybrids as potential EGFR-TK inhibitors and apoptosis-inducing agents
Development of new effective EGFR-targeted antitumor agents is needed because of their
clinical significance. A new series of imidazolone-sulphonamide-pyrimidine hybrids was …
clinical significance. A new series of imidazolone-sulphonamide-pyrimidine hybrids was …