Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

To date, the significant anti-cancer capacity of cold atmospheric plasma (CAP) on dozens of
cancer cell lines has been demonstrated in vitro and in mice models. Conventionally, CAP …

For cured meat products, nitrite is recognized for its antimicrobial effects against pathogenic
bacteria, even though the specific inhibitory mechanisms are not well known. Nitrite …

Post-translational S-glutathionylation occurs through the reversible addition of a proximal
donor of glutathione to thiolate anions of cysteines in target proteins, where the modification …

Selectively treating tumor cells is the ongoing challenge of modern cancer therapy.
Recently, cold atmospheric plasma (CAP), a near room-temperature ionized gas, has been …

The roles of superoxide (O2•−), peroxynitrite, and carbon dioxide in the oxidative chemistry
of nitric oxide (NO) are reviewed. The formation of peroxynitrite from NO and O2•− is …

Nitric oxide (NO) plays an important role as a cell-signalling molecule, anti-infective agent
and, as most recently recognised, an antioxidant. The metabolic fate of NO gives rise to a …

The mitochondrion is vital for many metabolic pathways in the cell, contributing all or
important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the …

Peroxynitrite, the product of the fast reaction between nitric oxide (• NO) and superoxide O
2•− radicals, is an oxidizing and nitrating agent which is able to traverse biological …