We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Plants are fascinating and complex organisms. A comprehensive understanding of the
organization, function and evolution of plant genes is essential to disentangle important …

Early genome-wide association studies (GWASs) led to the surprising discovery that, for
typical complex traits, most of the heritability is due to huge numbers of common variants …

RNA sequencing (RNA-Seq) uses the capabilities of high-throughput sequencing methods
to provide insight into the transcriptome of a cell. Compared to previous Sanger sequencing …

We summarize, in this review, the evidence that genomic balance influences gene
expression, quantitative traits, dosage compensation, aneuploid syndromes, population …

Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …

Genome-wide association studies (GWASs) have identified numerous risk genes for
depression. Nevertheless, genes crucial for understanding the molecular mechanisms of …

Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …

Expression quantitative trait loci (eQTL) mapping studies have become a widely used tool
for identifying genetic variants that affect gene regulation. In these studies, expression levels …

For many complex traits, genetic variants have been found associated. However, it is still
mostly unclear through which downstream mechanism these variants cause these …