While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …

Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

All rearranging antigen receptor genes have one or two highly diverse complementarity
determining regions (CDRs) among the six that typically form the ligand binding surface. We …

The T cell repertoire comprises αβ and γδ T cell lineages. Although it is established how αβ
T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting …

The tripartite subdivision of lymphocytes into B cells, αβ T cells, and γδ cells has been
conserved seemingly since the emergence of jawed vertebrates, more than 450 million …

Increased synthesis of heat shock proteins (hsp) occurs in prokaryotic and eukaryotic cells
when they are exposed to stress. By increasing their hsp content, cells protect themselves …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

Apurinic/apyrmidinic endonuclease 1 (APE1) plays a central role in DNA repair by cleaving
the DNA backbone 5'of AP sites that result from removal of damaged bases. New structural …

A common residue numbering scheme for all immunoglobulin variable domains
(immunoglobulin light chain lambda (Vλ) and kappa (Vκ) variable domains, heavy chain …

The specificity of immunoglobulins and α/β T cell receptors (TCRs) provides a framework for
the molecular basis of antigen recognition. Yet, evolution has preserved a separate lineage …