Immunotherapy has emerged as a key pillar of cancer treatment. To build upon the recent
successes of immunotherapy, intense research efforts are aimed at a molecular …

To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …

DJ-1/PARK7, a cancer-and Parkinson's disease (PD)-associated protein, protects cells from
toxic stresses. However, the functional basis of this protection has remained elusive. We …

Abstract Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors,
which are approved for cholesterol reduction, may also be beneficial in the treatment of …

MHC class I plays a critical role in the immune defense against viruses and tumors by
presenting antigens to CD8 T cells. An NLR protein, class II transactivator (CIITA), is a key …

The presentation of peptides to T cells by MHC class II molecules is of critical importance in
specific recognition by the immune system. Expression of class II molecules is exquisitely …

MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …

Despite increasing evidence of major differences between rodent and human immune and
neurological function, relatively few biomedical studies are performed with human cells. This …

The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …

By virtue of its control over major histocompatibility complex class II (MHC-II) gene
expression, CIITA represents a key molecule in the regulation of adaptive immune …