A primary function of the pancreas is to produce digestive enzymes that are delivered to the
small intestine for the hydrolysis of complex nutrients. Much of our understanding of …

Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

BACKGROUND & AIMS: The role of trypsinogen activation in the pathogenesis of acute
pancreatitis (AP) has not been clearly established. METHODS: We generated and …

Chronic pancreatitis is a disease of the pancreas in which recurrent inflammatory episodes
result in replacement of pancreatic parenchyma by fibrous connective tissue. This fibrotic …

Chronic pancreatitis (CP) is an inflammatory disease of the pancreas characterized by
progressive fibrotic destruction of the pancreatic secretory parenchyma. Despite the …

Ductal adenocarcinoma of the pancreas has an incidence of approximately 10 per 100,000
population per year. This number pertains to Europe, North America and parts of South …

Acute pancreatitis (AP) is characterized by edema, acinar cell necrosis, hemorrhage, and
severe inflammation of the pancreas. Patients with AP present with elevated blood and urine …

We investigated the biochemical properties and cellular expression of the c. 346C> T (p.
R116C) human cationic trypsinogen (PRSS1) mutant, which we identified in a German …

There are many reviews of pancreatic acinar cell function and also of pancreatic duct
function, but there is an almost total absence of synthetic reviews bringing the integrated …

BACKGROUND & AIMS: Acute pancreatitis is characterized by an activation cascade of
digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to …